Troopers responded to I-476 near northbound mile marker 67.1 in Washington Township around 10:45 a.m., Pennsylvania State Police said.
A cracked stud on a southbound Nissan Altima's wheel hub caused a tire to come loose and collide with the windshield and sunroof of a northbound Volkswagen Golf, according to state police.
The 66-year-old Golf driver from Oreland, and her passenger, a 68-year-old woman from Springfield Township, were taken to Lehigh Valley Hospital with non-life-threatening injuries, state police said.
Both women were wearing seatbelts at the time of the incident, police said.
The 19-year-old driver of the Altima was not injured, police said.
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